I could shoot my psychiatrist who was usually very good with medications. At 200mg on Wellbutrin I had the strangest experience.
I was sitting at the computer (so new?) and felt a "shift" in consciousness, it was BIG, I felt "something huge was about to happen", literally like an "awareness" or even more I thought, "The DP is going to go away, right now!" Then WHAP the WORST DP/DR I'd had in a looooong time.
Mind you, this is my personal experience. Some people swear by Wellbutrin. My doctor was using the logic that it would "perk me up", help my depression.
I was immobilized by it. Took me I don't know how long to get to the phone to call the shrink. I told him, "I'm having the worst DP in the world" and he said, "Well just stop it" and hung up. I think that was the beginning of the end of any real respect I've had for psychiatrists. He is/was very arrogant. Not one comforting word.
I swear I don't think mental health professionals in general know how horrifying the experience is. They DON'T GET IT.
The odd thing about Wellbutrin, and I think Joe said this, is that it has some "stimulant" effect. I don't know the chemical properties (could look them up), but it's not like an SSRI. I've had my best luck w/Celexa combined w/Lamictal/Klonopin and Nortriptyline (a tri-cyclic).
I have depression, as well as anxiety, DP/DR.
My vote on Wellbutrin is a negative. But there are many others here who have had excellent results with it.
As always, we are all Unique