Likely very individual so you can not take individual experiences and make the universel. Anti-Depressants in general have no effect on the core symptoms of depersonalization. They might help with general anxiety and depressive symptoms develop secondary to it. I tolerate the SNRI duloxetine far better than a SSRI despite it should be more potent. Nausea and vomiting might be a risk as a side-effect the first week in many so a low dose on 30.mg to start with is recommended.