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Hey,

i just discontiuned my Paroxetine (Paxil). On April 8th i have a apointment with my psychatrist finally again. Now i want to here from you which SSRI or SSNRI helped you the most, so i can ask him to try it out. I had already 4 different SSRI's, none of them had impact on my depression, neither my depersonalization. Of course i am gonna mix it with Lamictal.
 

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Likely very individual so you can not take individual experiences and make the universel. Anti-Depressants in general have no effect on the core symptoms of depersonalization. They might help with general anxiety and depressive symptoms develop secondary to it. I tolerate the SNRI duloxetine far better than a SSRI despite it should be more potent. Nausea and vomiting might be a risk as a side-effect the first week in many so a low dose on 30.mg to start with is recommended.
 

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Paxil and Effexor affected my sensation of orgasm. Instead of a ringing bell, I got a buzzer instead. I preferred the ringing bell, but did without it for the

20 years I was on Paxil and Effexor. Then I tried Lexapro (Escitalopram), and I was on 40mg and was told by a pharmacist that was a relatively high dose. I had zero side

effects from Lexapro, so I would recommend it with the caveat given by Mayer-Gross....your mileage may vary.
 
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