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Hi everyone!
I am 29 yo male. I have been diagnosed with DDNOS and OCD. I take these medications: Escitalopram (Lexapro) 20 mg in the morning, Aripiprazole (Abilify) 5 mg in the morning, Lamotrigine (Lamictal) 100 mg bid and Clonazepam (Klonopin) 1 mg at bedtime.
I have recurrent anxious dreams related to dissociative episodes, I have not real nightmares but I always wake up very confused. I tried tons of meds to treat this issue, but nobody knows the key.
I would like to know is there is someone with my same sleep issues and which medications have helped.

Many thanks!
Marco
 

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You could try to increase lamotrigine to 2-300.mg. In those trails done in depersonalization with lamotrigine the doses used was typically in that range. Benzodiazepines in can be helpfull for some but tolerance seems to develop to them very rapidly.
 

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You don´t need to divide lamotrigine into several doses. The half-life is very long like 25-30. hours and you will come into a steady-state at some point. You can divide it into two but I don´t think it necessary when it is not related to epilepsy. 50% sees some benefits for a combination of lamotrigine and an antidepressant. You can try what can be tolerated. Very difficult to give specifics advice as the depersonalization research unit is closed but a researcher wrote to me some years ago that the tried most people in the dose of 2-300.mg and some few benefited from going as high as 500.mg.
non-benzodiazepines to sleep on might vary from country to country depending on what is approved and also what can be tolerated. Some uses low doses of mirtazapin, Quetiapin. I don´t know if melatonin is used. Sometimes antihistamines that is also used for transportation sickness like prometazine is used.
 

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Yes. I can see it is sold as "bluefish" and also used for anxiety. So, if your insomnia is related to anxiety it could likely be used. Most tend to avoid using benzodiazepines as the a highly addictive, tolerance comes fast and often the effect stops. So, you likely have to think of a substitution of clonazepam.
If you have anxiety there are some who have benefited form pregabalin or Lyrica. You could try it if lamotrigine fails.
 

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Thank you for your reply. Now I take Lamotrigine 200 mg/day. So can I go to 300 mg/day in split doses? e.g. 200 mg in the morning and 100 mg in the evening?
My psychiatrist didn't ask me to split doses. Also he asked me to increase the dosage only 25 mg a week. As the rare side effects can be pretty serious I think it is important to follow your psychiatrists instructions.
 
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