I'm still on Topamax. My Depersonalization came back, full force. Mostly because I'm in a lousy place, mentally and emotionally. It's given me back my emotions. If I feel bad, I feel bad, not as numb as I used to be. When I have good personal experiences, it feels better than it did.
I believe that Topamax will help me with my depersonalization in the summertime, when I do better mentally.
For my history:
I've tried benzodiazepams and I found that they work a little bit for about 3 weeks, then they poop out, then there's 3 or so weeks or withdrawl. For most people, they're not worth taking.
For those of you who like benzodiazepams, but find the useful effects short term, like I did, you should look into some of the anti-convulsants, which like the benzodiazepams, also affect the GABA neurotransmitter.
Since Depersonalization disorder is a trauma-based disorder, it makes sense (to me) that it would have similar treatments to Post Traumatic Stress Disorder. I have a dual-diagnosis of PTSD and DP Disorder.
Feel free to join my Complex-PTSD group, here:
http://health.groups.yahoo.com/group/complex_ptsd
Also, for medications, check out the links section of the above group, and this link:
http://www.adaa.org/AnxietyDisorderInfor/chart.htm
Michael