I've been reading "Overcoming Depersonalization Disorder" and I agree that dp can come from substance abuse or it can come "naturally" (from trauma or other disorders); consequently it may cause imbalances in the brain and wrong thinking patterns. In my opinion, chemicals imbalance can cause distorted thoughts/perception and the other way around as well. The point is if it's true, what kind of therapies could help us in solve this problem? The book mentions CBT in general, but, I've tryed it twice and had no results... I always think that dp affects us in a way deep level to the point we don't recognize ourselves anymore and question reality and techniques given by this approach like "think about something else", "try to prove your temporary beliefs are wrong" are too superficial. Maybe psychoanalysis would do a better job since it allows us to revisit our past and rediscover who we are? What do you guys think?