I believe mine is from being isolated. I was very active in my career and then retired, so started up an online gift shop. That went well for several years, kept me very busy here at home and then business took a nose-dive for some reason, so I closed the store. Then the anxiety/depression struck while sitting here at home and depersonalization and derealization hit me when I would take a short drive with hubby to a store across town or whatever. Idle minds are the devil's workshop and mine sure turned on me when it had nothing else to do. I have to make an effort to get out every day, even if it's just to drive around town a little bit. I will conquer this. I will not let my life be controlled by this.