I went off Zoloft the other day after several bad weeks of increasing the dosage under my psychiatrist's direction and suffering worse and worse depression and anxiety. Went down from 150 to 50 in three days and then to nothing, and I have never felt better in my entire life. Had been on Zoloft successfully at 50 mg for 12 years and started having panic attacks and depression bigtime May 21, 2005. No drugs of any kind for 2 days now and I feel wonderful. Makes no sense, but I report it anyway for what it's worth.