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There is no medicine formally approved for depersonalization. The trails done with medicine have been very small and not placebo controlled. However there are some who have a benefit of a combination of a antidepressant with lamotrigine. As antidepressants SSRIs or SNRIs are typically used and the dose of lamotrigine is typically within the rage of 200-300.mg. It will take months to reach a dose of 200-300.mg as it is normally increased with 25.mg pr.week to avoid a skin reaction. You can give that a try.
 
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