[Carpacano]

Recently I went into a frenzy of cure-seeking research and found myself re-reading the wikipedia pages about depersonalization and dpdr. To my surprise i found them totally re-done with some information like rTMS removed (thank god) and some added. The added information in question was about treatment efficacy of naloxone and lamotrigine. So I'm asking: anybody here has had any experience with those two substances? I will very likely try naloxone (and maybe you could to the same) since:
1) It's very cheap
2) Has almost no side effects and is as safe as it can be
3) I already have experience with intramuscular injection drugs
And will report back. I'm not very sure about Lamotrigine (though I will try to talk about it to my psychiatrist) since it's potentially very dangerous.

 

[Carpacano]

I dont understand the posts reference to wiki. Wiki says that rTMS trails shows the rTMS at the right TPJ might be helpfull to 50%. It really don't point towards naloxone or naltrexone as being a treatment.

In medicin 50% of findings or cures can not be replicated. There is a reason to 50% can't now as fraud, to small samples, high placebo effect, biases among researchers and patients. Research in depersonalization might have a replication crisis much higher than 50% because research in it is very underfunded. It is very difficult to get money for research and one donor stopping making contributions might close down research totally as it happened with the depersonalization research unit. So, everthing is small in size, no placebo group no follow up. So, it is close to claims.
The Fuller "trail" is very small 12. patients. It is a pilot study to test the idea that the opiopate system is involved in depersonalization. It is not a trail for a treatment, there is no follow up as if was a trail. It is a pilot study to see if the opiopate system plays a role. It have not be replicated by others to show it findings is false or correct. People read it as a "trail" for a treatment as they also think a trail is a "free treatment" and a "research unit" is a "treatment center"- the narratives says it has to be like that so they think that.

Naloxone is an antagonist at the opiapate system given to accute overdoses to opioids. It is used to stop people form going into a respiratory crises and sleep to death from an overdose.

It has to be given I.V and it have a short half-life of close to an hour. That also makes it unusable for a treatment.

One on this site, one called "huggybear" from Schizerland who have had all his posts and profile deleted wrote some years ago that he had his insurance to paid a serval infusions at a hospital for several hours in the highest dose as in the Fuller study,- felt nothing.

Yeah, just like rTMS, it's a shot in the dark since studies about it are very limited. I think I'll try naloxone anyway, since I've read it's safe, and won't hurt to try at all since it's so cheap. Regarding use, i guess it can actually be usable for treatment because it can either be administered intramuscularly and snorted. If I try, i'll do the former and report back, but I don't have any expectations. Having them utterly destroyed by rTMS taught me this lesson already.

 

[Carpacano]

What effect did TMS have on you? Which area was targeted?

None. In fact, It made things worse (but It was probably just nocebo). I think it was the right temporoparietal junction.