Depersonalization Support Forum banner


8425 Views 11 Replies 3 Participants Last post by  Broken
Thought I would start a separate thread for this one. I have tried many many supplements over the years. Lions Mane mushroom, which I started 3 weeks ago seems to be making the most difference. I had 2 teaspoons in my coffee a week ago, but felt 'nauseas and lightheaded'... not taking into account I wolfed down my breakfast and cycled 3 miles quickly as I was late.. At that time I had a small but significant shift in DR symptoms. More depth, more colour, more embodied.

Today I did this again, and wow. Feel less DR again, but without the nausea (was probably exercise related). FYI there is a kappa agonist called Erinacine E that is released from the broken down polysaccharides.. I take wood grown, double extracted (water and alcohol), 30% polysaccharide powder in my coffee. A teaspoon is approx 3g, so I will now take 2 as all the studies used 5g. Also, Lions Mane interestingly is a FOOD so seemingly lower risk than herbs etc

One symptom of it 'working' is itchy skin, which is attributed to the increase in Nerve Growth Factor (NGF) growing new nerves. I think there may be more at play though. Kappa agonists are extremely effective at STOPPING itching. So, I believe it may in fact be a sign that the Kappa opioid receptors are downregulating, altering our 'itch threshold'. Just a theory, very out there, but who knows. All I know is it helps, and continues to help (as does CBD oil which I also take- but the effect has plateaued).

Also, wanted to discuss MICRODOSING magic mushrooms. Taking 0.2g every 4 days is meant to help lift depression, ptsd etc. Big doses have also been shown to transform these conditions, but in my state seems like a big risk, and microdosing anecdotally brings immediate relief. Psilocybin increases connections, in the brain and neurogenesis. People curing stammers, depression, ptsd, anxiety in one trip is not unheard of.. after some months microdosing I may try this. I am in the uk however, and it is a class A drug... so I am pretty scared about that. The 'snoopers charter' means all internet history is recorded in the uk. Finding access to some is going to proove very difficult as I have more or less given up on socialising as I am so dysfunctional. Thoughts, feelings, anyone in uk?
See less See more
  • Like
Reactions: 1
1 - 2 of 12 Posts
At that time I had a small but significant shift in DR symptoms. More depth, more colour, more embodied.
That's interesting in reference to lion's mane, because I just read an article that says:

You may not experience the effects of supplementing with Lion's Mane Mushroom immediately. But many users report with continued use of Lion's Mane, a boost in mood and mental energy.

Some report it increases depth perception. And an improvement in sense of smell.

So I immediately thought this may help people with DR to which you also testify.

Lion's Mane also helps:

  • Nerve Growth Factor. Lion's Mane Mushroom prevents and treats nerve damage in the brain. Once past the blood-brain barrier, Lion's Mane stimulates enzyme production that release Nerve Growth Factor (NGF). Nerve regeneration helps relieve neurodegenerative disease symptoms such as Alzheimer's, dementia, and Parkinson's Disease.
  • Neurogenesis. Lion's Mane stimulates the repair and creation of neurons. Boosting neurotransmitters and signaling that effects memory, learning, recall, and mood.
  • Brain Optimization. Lion's Mane helps eliminate brain fog. Restoring memory and mental alertness. And improves anxiety and depression symptoms.

BTW let us know how your shroom trip went down. ;-)

Psilocybin switches down the mpfc which is overactive in dp. It also switches down the hypothalamus which might be involved in dpd.
I had to look that up (mpfc=medial prefrontal cortex? ) which is involved in memory and decision making and I just learned that lion's mane is also good for that. I'm currently trying lion's mane which I feel helps me sleep better, but also modafinil for more energy. I'm not sure if both may work against one another a bit, so should try them separately..

BTW are you sure that mpfc is overactive in DP or is it underactive? Because I just read that depression and schizophrenia is linked to lower activity of the mpfc.
See less See more
About psilocybin:

Nutt's group is looking into using the drug to treat depression, and this week in The British Journal of Psychiatry, he and colleagues report that psilocybin can increase neural activity in brain regions related to memory when people recall events from their past. The drug also improved people's ability to access personal memories and related emotions, which the researchers say could be helpful during psychotherapy.

Psilocybin has a similar chemical structure to serotonin - a hormone involved in regulating mood - and therefore binds to serotonin receptors on nerve cells in the brain. The drug may have therapeutic potential because the serotonin system in nerves is also a target for existing antidepressants.

A study earlier this year by Charles Grob at the University of California, Los Angeles, showed that people with end-stage cancer had significantly less anxiety and better mood after receiving psilocybin

Franz Vollenweider, who works in a similar field at the Psychiatric University Hospital Zurich, Switzerland, says that the immediate effects of psilocybin are not as important for clinical benefit as the longer-term effects. That's because psilocybin increases the expression of genes and signalling proteins associated with nerve growth and connectivity, he says: "We think that the antidepressant effects of psilocybin may be due to a possible increase of factors that activate long-term neuroplasticity."
See less See more
1 - 2 of 12 Posts
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.