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Discussion Starter · #1 ·
So I happen to live close enough the the Mt. Sinai school, called them this morning and passed my telephone screening, lol :roll:. So now I can make an appointment to go in and see Dr. Daphne Simeon. i found out that so far they've only had "about ten" participants in their research. k, what about the meds? they were very reluctant to tell me what they are, until i said the words "yes, i'm interested in the program" (huh???)cycloserine (seromycin), cyproheptadine (periactin)...i just read someone else's post (cynthia?) and the meds she was told about were completely different. well, at least none of these meds have a bad rep of benzos.

would you do this?? would you be a research guinea pig??
-rula
 
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I'd love to do something like this because i'm jobless and strapped for cash. I'm sick of selling my blood which i must've done about 20 times by now. I figure the Sanai school must be thousends of miles away anyway.
 

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Discussion Starter · #4 ·
yea, it's all free and they do a lot of monitoring...every 2 weeks blood tests and a session with Dr. Simeon.

at the very least maybe i'll get the gist of Simeon's new DP book :wink:

-rula
 
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I should go for it at least youre monitored.... and periactin is nothing, not a real med, it's almost over-the-counter med for allergies!!! So, don't worry.

C xxx
 

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So the current state-of-the-art contender for depersonalization disorder therapy, being researched by the world's leading authority on the subject is...
an antihistamine, and a drug for treating tuberculosis.
Am I missing something, or have they just got bored and decided to go all surreal?
 

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Discussion Starter · #10 ·
Weymouth Stan said:
So the current state-of-the-art contender for depersonalization disorder therapy, being researched by the world's leading authority on the subject is...
an antihistamine, and a drug for treating tuberculosis.
Am I missing something, or have they just got bored and decided to go all surreal?
exactly my first thoughts too...but both drugs had "anxiety" listed under "other treatments"...i certainly plan to ask the Dr. about her theories on how an antibiotic works to cure DP.
 
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I wish I could be a martyre for this cause but I doubt an anti-histamine will do jack for us and they'll be no dp free parades any time soon. I took allegra D and it didn't do shit except clear my sinsuses so I could coat them all over gain with tobacco soot.
 

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I think antihistamines actually work for DP. I took benedryl (Diphenhydramine) and it actually made me feel better. I think that they are trying to do something with sleep in their research. Who knows, but they are the experts, so they must have some clue. I also read that cycloserine has been used in the treatment of schizophrenia.

In animal studies, indirect stimulation of the NMDA receptor reversed the effects of NMDA receptor antagonists and enhanced cognition. This strategy has shown promise in double-blind, placebo-controlled clinical trials, as well. These trials focused primarily on schizophrenia treatment with the full NMDA receptor agonists glycine and D-serine, the partial agonist D-cycloserine, and the glycine transporter-1 agonist N-methylglycine.
 
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Who needs a doctor-supervised treatment to become a martyre? My medicine cabinet is crammed with random drugs...i'm just going to lock myself in there and not come out until i'm cured or i run out of drugs. Then i'll just become reverse santa claus and go to the nursing home down the street.
 
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Encouraging....

Depersonalisation disorder:
a contemporary overview
by
Berrios GE, Sierra M.
Simeon D.
Department of Psychiatry,
Mount Sinai School of Medicine,
New York, New York, USA.
CNS Drugs. 2004;18(6):343-54

ABSTRACT
Depersonalisation disorder is characterised by prominent depersonalisation and often derealisation, without clinically notable memory or identity disturbances. The disorder has an approximately 1 : 1 gender ratio with onset at around 16 years of age. The course of the disorder is typically long term and often continuous. Mood, anxiety and personality disorders are often comorbid with depersonalisation disorder but none predict symptom severity.The most common immediate precipitants of the disorder are severe stress, depression and panic, and marijuana and hallucinogen ingestion. Depersonalisation disorder has also been associated with childhood interpersonal trauma, in particular emotional maltreatment.Neurochemical findings have suggested possible involvement of serotonergic, endogenous opioid and glutamatergic NMDA pathways. Brain imaging studies in depersonalisation disorder have revealed widespread alterations in metabolic activity in the sensory association cortex, as well as prefrontal hyperactivation and limbic inhibition in response to aversive stimuli. Depersonalisation disorder has also been associated with autonomic blunting and hypothalamic-pituitary-adrenal axis dysregulation.To date, treatment recommendations and guidelines for depersonalisation disorder have not been established. There are few studies assessing the use of pharmacotherapy in this disorder. Medication options that have been reported include clomipramine, fluoxetine, lamotrigine and opioid antagonists. However, it does not appear that any of these agents have a potent anti-dissociative effect. A variety of psychotherapeutic techniques has been used to treat depersonalisation disorder (including trauma-focused therapy and cognitive-behavioural techniques), although again none of these have established efficacy to date. Overall, novel therapeutic approaches are clearly needed to help individuals experiencing this refractory disorder.

+++++++
 
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I can't see the abstratc...... argh :)

2005

Sierra M, Baker D, Medford N, Lawrence EJ, Patel M, Phillips M, David AS (2005 submitted) Lamotrogine in the Treatment of Depersonalisation Disorder. Journal of Psychopharmacology. see abstract

If someone can see it, tell me

C xxx
 

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Discussion Starter · #17 ·
Cynthia said:
I can't see the abstratc...... argh :)

2005

Sierra M, Baker D, Medford N, Lawrence EJ, Patel M, Phillips M, David AS (2005 submitted) Lamotrogine in the Treatment of Depersonalisation Disorder. Journal of Psychopharmacology. see abstract

If someone can see it, tell me

C xxx
Sierra M, Baker D, Medford N, Lawrence EJ, Patel M, Phillips M, David AS (2004 submitted) Lamotrogine in the Treatment of Depersonalisation Disorder. Journal of Psychopharmacology.

Depersonalisation disorder (DPD) is the persistent subjective experience of unreality and detachment from the self. To date there is no known treatment. Lamotrigine as sole agent was not found to be effective in a previous double-blind randomised crossover trial although open trials were encouraging. We carried out an open label trial of lamotrigine in patients with DPD seen in a specialist clinic. The majority were also receiving other medications, mostly selective serotonin re-uptake inhibitors. 32 patients agreed to participate and had complete follow-up data. 16 (50%) showed a significant improvement (mean 40%) in their depersonalisation symptoms, as rated by standard and novel scales, assessed 16.6 months after commencing treatment. Concomitant symptoms of depression also showed improvement but this did not account for the specific effect on DPD. There were no serious adverse effects. The results of this trial suggest that a significant number of patients suffering from DPD may respond to lamotrigine, particularly when combined with antidepressant medication. The results are sufficiently positive to prompt a larger controlled evaluation of lamotrigine as ?add-on? treatment in DPD.

but I think Mt. Sinai is abandoning lamotrigine for now, i'll find out later on today. someone on the MSN DP board had an appointment with Dr. Simeon this morning. -r
 

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Discussion Starter · #19 ·
Universal said:
i've also been thinking about going over to have a talk with Dr. Simeon. I should probably do that asap, no? hey rula how has your experience with mt.sinai been?
I never finished my thread on my experience at Mt. Sinai, cuz as they say, if you have nothing good to say, probaby best not to say anything at all. :wink:

Let's just say that as long as you keep a few things in mind when you go see Dr. Sensitive (as us lab rats later nicked named her) then your experience could be more positive than ours.

first, you're not going to be dealing with a therapist but a researcher. She will not bother with things like showing concern or empathy. it's dry scientific data collection.

She will make you sit outside in the hallway to fill out questionnaires despite the fact that there's plenty of room in her 2 sections office. No one understood exactly why, but it bothered us!

Although your agreement with her includes 20-mins of talk therapy, you'll never actually get that. it's basically here's a pill come back in 2 weeks and fill out more questionnaires. (therapy funding was apparently cut)

The questionnaires themselves have a lot of questions that seemed irrelevant, more about multiple personality disorder. gets really annoying to have to fill them out every 2 weeks...no, i don't find myself wearing clothes i didn't remember putting on, that's not dp/dr :roll:

If you're prepared to deal with all that, then go for it. but before she'll take you in, you have to be stable, meaning no change in meds/dosage whatsoever in at least 2 months. The first med gave me lock jaw and i stopped it after 2 weeks. I felt no improvement in my symptoms after med #2 either, that one lasted 4 weeks. someone else who finished the fulll 8 weeks said it "helped release pressure in her head" but she's not fully recovered either.

I don't really think Dr. S is on to anything yet, no cure in the near future. If i were you i'd give my body a break, and not pump it full of experimental meds.

-ru
 

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ahh, bummer. that's not good news at all. at least i have you to report it to me! hehe. well whatever, i guess there's obviously no fast cure. is 20 minutes of talk therapy worth it? i guess i better go find me a good shrink...
 
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