I definitely have times where i feel more and less depersonalized (and hopeless). I have heard this called "setbacks" as well. But the setbacks are VERY common and happen quite frequently, so I don't know if they are really setbacks or just the ebb and flow of emotions that we are maybe just more attuned to because of our inner focus and "watching" and amped up nervous system. I dunno.. I just think over fairly long periods of time they are slowly getting better and our systems are working their way back to homeostasis as long as we are getting the right treatment and doing the right things.