Discussion Starter · #1 ·
There was a lot of discussion going on in another section of this site about the effect of cortisol or its link to DP/DR. I know Doctor Simeon is exploring this trail in her studies right now. I have read a study stating that Mifepristone (RU-486) was of great help for people with major depression and psychotics features. This med block to a certain level the impact of cortisol on neurons (cortisol is toxic for young neurons). Many Dp sufferer seem to have lower level of cortisol than "normal" subject. Maybe this is some kind of reaction of the brain trying to protect it self. Maybe DP sufferer have neurons that are more sensitive to the toxic effect of cortisol witch the brain would try to fix by lowering the level of cortisol. Also serotonin is in competition with cortisol on certains receptors of the neurons witch could explain why ISRS help some of us. Maybe trying a drug like mifepristone could have some impact on DP/DR. I guess no one on this site ever tried that drug since its been mostly used in small trial. Anyway this is just a theory... I would appreciate the input of someone who tried it if someone did.