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Hello folks! I'm a 25 y/o guy who has been suffering from an unknown disorder for the last six years. It is one terrible journey, full of misery and pain, but such is life, and I learned to appreciate what was given. That being said, my intention is to fight till I completely run out of ideas, and for the first time in many years I finally have something to grab onto.

Symptoms: Intense Brain Fog - mental capacity at 15%, numbed out, blank mind; Derealization - perceptional dissociation, observing myself from 3rd person perspective; Chronic Fatigue - physical capacity at 20%, feeling like a heavy, old, empty battery; Poor circulation - dead-white extremities and dull skin/muscles; Excessive Daytime Somnolence - feeling as if I've never slept.
*Everything gets 3x worse after shower (hot/cold) - I basically sleep afterwards, otherwise I'm unable to function.
*Everything gets 2x worse if I sleep less than ~7hrs a day.

Background: Grew up in a healthy and loving environment. Amazing childhood, nothing but happiness and beauty. Never had emotional burden or any kind of trauma. Same with teenage years, free of any psychological or physical issues whatsoever. Excelled in school and social activities. Developed a charismatic, cheerful and dynamic personality. Health-wise I've never had any ailment and sincerely don't remember the last time I've been sick. My body is quite strong, with athletic conditioning and fine nutrition. All in all, lived a perfect life.

How it started: Out of the blue, I gradually noticed difficulty formulating sentences, followed by unusual lack of energy and increased need for sleep. This happened in the span of several months, and I simply cannot pinpoint the catalyst. I was in college during that time, minding my own business and having fun, while stress levels were kept at the minimum. Also no drugs of any sorts were involved. Naturally I got frustrated of what was happening, but I thought it would all resolve come summer holidays. It only got worse.

What I've tried:
Conventional Medicine
80+ doctors from all over the world
100+ tests, analyses, scans (all clear - Healthy™)
10+ medications (psychotropic - Modafinil, Wellbutrin, Effexor, etc)
*Tested for most DR/CFS theories

Alternative Medicine - Herbal / Chinese / Ayurveda / Chiropractic / Homeopathy
50+ doctors from all over the world
800+ herbs, tonics, exercises

Supplements
1500+ extracts, adaptogens, nootropics, performance enhancers, immune boosters, etc

Experiments
Lifestyle changes (isolation in nature, social immersion, full on leisure, full on work), various diets, megadosing supplements, different methods of exercise; polyphasic sleeping, dry fasting, maximum sensory pleasures, maximum mental stimulation, triggering fight/flight, adrenaline rushes, etc

Spent thousands of hours reading resources online.

Let's just say that I've tried quite a few things over the course of the last six years, and nothing, I repeat nothing has even the remotest effect on my condition. To get the rough idea, if I megadose (3k mg each) on Modafinil + coffeine, the alertness level moves only about 2-3%. That's it. There's nothing that makes me feel worse (except shower & lack of sleep) or better. I'm just stuck in a flatline mode of being.

What I haven't tried: most CNS stimulants; Atypical antipsychotics; Party drugs; Psychadelics.
I'm a little wary of these classes of drugs, but since I'm trying everything, they're also on the list. Out of those that fall into the aforementioned categories, my research showed that one of the mildest and easiest options to begin with was Mescaline (delicate psychadelic/euphoriant). And so I gave it a try.
*Medical testing showed no abnormalities, therefore mainstream neurologic drugs are my only option.

The short-lived miracle: Since Mescaline is illegal and quite possibly non-existent in my country, I went on a trip to South America, where I got hold of Peruvian Torch cactus powder. There are several other cacti species that contain Mescaline, but Torch provides the purest experience since it contains only a handful of other alkaloids. At first I prepared 100g (above average dose) powder by boiling it. I drank and waited 15 hours (usually starts in 1hr and fades away by the 10th) for any kind of effects. Nothing but an uneasy feeling in the head, as if something got stuck. For the second time, I ingested the raw powder of the same amount. The feeling? even worse. Imagine having tons of highways in the head with massive traffic jams all over the place. This is how it felt for about 13 hours. By that time I really wanted to sleep, but the feeling was too uncomfortable, so I went outside for a walk. While roaming in the streets, I was slowly noticing something unusual - the motion of walking felt in sync with my sense of awareness. The dissociation was melting away, and my perception coming back. The mind/body connection was getting stronger, and the veil of fog was being lifted off my brain. My hands immediately went from cold/white to warm/red. The fatigued muscles became lively and energized, and the mental faculties were going full throttle, back to where I left them years ago. I couldn't believe what was happening and how it was happening. My screams of joy were being heard in the whole town. It went on like a rebirth really. And mind you, all of this felt very clean and organic with practically no signs of classic Mescaline experience (open/closed eye visuals, distortions, dream-like state, altered perception, synesthesia, hallucinations, exaggerated emotions, sense of floating). So just like that, in the span of three hours, I recovered 100%. Also completely forgot how I felt for the last six years. It was beautiful. Not long after, my legs started cramping, with blood rushing up and down in an insanely strange manner. Didn't know what was happening so I want to ER, where they gave me some kind of a sedative that knocked me out for two hours. When I woke up, my legs were back to normal, and I was still feeling fantastic, fully relieved from the disorder. I went home, celebrated the day, and went to sleep. The next morning I woke up with the same old terrible condition, but renewed faith.

This was undoubtedly one of the best days of my life. After walking in the dark for so long, I finally saw the glimpse of light, and my hope rekindled. Now I'm going to explore Peruvian Torch (3 methoxytyramine, Tyramine, Mescaline, Two unknown alkaloids, and 3,5-dimethoxy-4-hydroxyphenethylamine) and Mescaline's mechanisms of action to discern what might have happened that day, and where is to be found the root of my disorder. We CAN recover folks, don't lose your optimism and motivation. I will be meeting with several neurologists in the upcoming days, and will be keeping you updated. I would be extremely grateful for your thoughts and suggestions of any kind. Maybe some of you have ideas on what to look for, try, or talk to the doctors about. I hope this becomes a success story and a resource for battling this nasty disease.

Wish you all a complete recovery!

*It took me one full day to write this; normally it would've taken much much less.
 

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Thanks for sharing your experience. this drug is illegal in my country and I can't travel to another country to get it. what's important is to understand the mechanism of the drug, where the problem is in our brain. and possibly look for something that works like it does.
 

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Good news! The brain pathways that are needed to 'feel normal' are still there, just deactivated. I have been following a similar route recently but with magic mushrooms. Psilocybin and mescaline both act in similar ways through the 5HT2a receptors. This can induce 'dreams states' or hallucinations and reboot the brain.. I had amazing experiences with shrooms recently.

The issue being, I want to take a larger dose to get the 'reboot' effect but vomit as my body cannot handle it. But the DP did seem to fade in an odd way, muscles relaxed that hadn't for years.. walking became weird but I felt more embodied and solid. I felt happy and connected. The higher doses could lead to 'bad trips' but I am aware of this and know I have bad things to access and reconnect to.

Good for you anyway. I have completely changed my mind towards SOME drugs recently. They could be of benefit to some, and I certainly have found them beneficial. Sadly microdosing doesn't seem to have the same effect. I will be taking another large dose later this week with a small amount of food and ginger to prevent vomiting.. will report back when I do!
 

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This is very interesting as I had read this article, and experienced something similar a few months later. I had tried a nasal dose of Narcan (naloxone) and cannot fully remember if it was the same day, or the next day, I had experienced 80% improvement for a few hours until I went to sleep, and woke up the same old feeling the next day. Of course I tried it again a few weeks later, and nothing. Really was a life changing experience that there is hope on the other end, I have been dealing with this for 3 years now.
 

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Wow, just seeing this now. So inspiring. I may try microdosing mescaline at some stage. I would be too fearful of a full dose. Please report back with any new findings or even theories. What did the neurologists say?

This is very interesting as I had read this article, and experienced something similar a few months later. I had tried a nasal dose of Narcan (naloxone) and cannot fully remember if it was the same day, or the next day, I had experienced 80% improvement for a few hours until I went to sleep, and woke up the same old feeling the next day. Of course I tried it again a few weeks later, and nothing. Really was a life changing experience that there is hope on the other end, I have been dealing with this for 3 years now.
Fascinating. This has been the case for several people, both the improvement and the subsequent lack of efficacy. Were there any lasting improvements?
 
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