I've had excellent results with a combination of Lamictal (lamotrigine), Zoloft (sertraline), and Tofranil (imipramine). Klonopin (clonazepam) makes the cocktail work even better, but unfortunately it is too sedating for me. FYI, my own doses are 300 mg Lamictal, 25 mg Zoloft, 10 mg Tofranil. High Lamictal, low Zoloft, miniscule Tofranil seems to work best for me. Interestingly enough, this is close to the cocktail Dreamer describes. Lamotrigine + SSRI + TCA (tricyclic antidepressant) + Klonopin.