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Discussion Starter · #1 ·
I've had excellent results with a combination of Lamictal (lamotrigine), Zoloft (sertraline), and Tofranil (imipramine). Klonopin (clonazepam) makes the cocktail work even better, but unfortunately it is too sedating for me. FYI, my own doses are 300 mg Lamictal, 25 mg Zoloft, 10 mg Tofranil. High Lamictal, low Zoloft, miniscule Tofranil seems to work best for me. Interestingly enough, this is close to the cocktail Dreamer describes. Lamotrigine + SSRI + TCA (tricyclic antidepressant) + Klonopin.

Marjorie
 

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thanks, marjorie. This kind of specific data is extremely helpful. This Lamotrigine stuff is the only thing I have seen so far that is idicated specifically for depersonalization, when suplimented with SSRI. And so it is really interesting. I will be able to add my own data in perhaps a few months. Thanks again.
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Discussion Starter · #3 ·
Dear Dalailama15,

I'm glad this is helpful. A three or four-part cocktail can sound daunting, but the Zoloft is a very mild dose and the Tofranil is way below standard doses. Occasionally, when I can manage the time, I'll take 4 mg of Klonopin, and the clarity the next day is wonderful. But I haven't figured out how to schedule life around 12-14 hours of sleep.

Back in the days of Andy's board, I wrote that no matter how I lowered the dose, Klonopin was making me drowsy and more out of it. Someone there suggested that instead I needed to raise the dose, rather than lower it. I've found this to be absolutely accurate. Either way I need to sleep for a long time, but on the high dose I feel very clear headed when I am awake.

I hope that some clinicians and researchers do actually monitor this board. I can understand their reluctance to identify themselves, but it would be nice to know our experience is going somewhere where it can help others.

Best,

Marjorie
 
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Discussion Starter · #4 ·
We must have been posting at the same time. Ah, name that SSRI . . . beats me. I've never taken anything but Zoloft. Wish I could be more helpful. Marjorie
 
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Discussion Starter · #5 ·
betty said:
I am starting on Lamotrigine tommorow have to suggest an SSRI but don't know which would be best any suggestions??

I hear that Celexa is good but isn't that a newer form of Prozac as I did not get on well when on Prozac.

any input would be gratefully recieved.
Lamictal is a great choice,, Celexa is an SSRI, but in some forms in considered to be bicyclic due to its blockage of dopamine H2 receptors, but it does not affect these receptors as much as TCA's do, so it is still classed as an SSRI.

If by saying Prozac did/nt help you, Celexa always could help, if not another good choice would be Effexor.
But i still say adding Klonopin to any meds for DP is a must, it is not just a benzo, but it is an anticonvulsant and has some antidepressant properties in low doses..
 
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Discussion Starter · #6 ·
betty said:
I am starting on Lamotrigine tommorow have to suggest an SSRI but don't know which would be best any suggestions??

I hear that Celexa is good but isn't that a newer form of Prozac as I did not get on well when on Prozac.

any input would be gratefully recieved.
Lamictal is a great choice,, Celexa is an SSRI, but in some forms in considered to be bicyclic due to its blockage of dopamine H2 receptors, but it does not affect these receptors as much as TCA's do, so it is still classed as an SSRI.

If by saying Prozac did/nt help you, Celexa always could help, if not another good choice would be Effexor.
But i still say adding Klonopin to any meds for DP is a must, it is not just a benzo, but it is an anticonvulsant and has some antidepressant properties in low doses..
 
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