I was on prozac about 6 months. Felt nothing from it and it made me whacky when I was drunk lol. I have tried many drugs and the ones that helped the most were effexor and Imipramine (both increase serotonin and norepinephrine). And CBD helps as well. I think being able to relax enough to get into a deep sleep is a vital part for my DP and anyone with DP who has sleep issues (imipramine helps with this). And fluoxetine didn't affect appetite, sleep or mood for me