SSRIs are thought to be good at treating DP/DR. I was originally prescribed Escitalopram when I was diagnosed with depression. But my doctor said it will also help with my depersonalisation feelings. I think combinations of anti depressants are effective at treating DP/DR but as with all mental disorders they only treat the symptoms. To eradicate it completely I believe you have to sort out your anxiety/depressive issues through therapies and positive thinking.
A forum community dedicated to support for those living with depersonalization disorder. Come join the discussion about treatment, health, life styles, spirituality, medication, research, recovery, and more!