[azteca2]

I'm wondering if the blank mind/feeling mentally disengaged is like the psychomotor retardation described in some people with depression. I recently had a SPECT scan showing hyperactive medial pfc and thalamus. The same areas in the depression study by Dr. Liston for the subtype with high anhedonia and psychomotor retardation. If so, maybe I just have a strange form of depression. My next step is likely to find a TMS provider who will work with my specific situation .

 

[TDX]

I'm wondering if the blank mind/feeling mentally disengaged is like the psychomotor retardation described in some people with depression. I recently had a SPECT scan showing hyperactive medial pfc and thalamus. The same areas in the depression study by Dr. Liston for the subtype with high anhedonia and psychomotor retardation. If so, maybe I just have a strange form of depression. My next step is likely to find a TMS provider who will work with my specific situation .

I haven't seen the studies you mention, but I think it is thought that psychomotor retardation is supposed to predict response to Electroconvulsive therapy. However I doubt that the blank mind can be understood as a type of psychomotor retardation. Nonetheless I will try ECT in the future, probably when I get the chance to try kappa-opioid-antagonism and it doesn't work. I'm very much in the same place as you, including the diagnostic

When it comes to TMS and depression I think you should not have too high expectations. Although it is approved for depression the standard protocol seems to be widely regarded as disappointing and I think I read that patients with anhedonia are the ones who do not benefit from it. Generally TMS has been tried for for many things in the last decades, but it isn't really establised for anything.

 

[azteca2]

I wouldn't want the standard TMS they do for depression. It would have to be an off-label use of TMS. Maybe an inhibitory stimulation to the medial pfc. I think ECT could actually be helpful. Maybe it could break up the hyperactive pathway from the frontal lobe to the thalamus. And google depression subtypes by Conor Liston, it was a recent study.

 

[azteca2]

From his neuroimaging study we at least know that anhedonia and psychomotor retardation are highly prevelant in the same patients. But they may be a more standard case of depression. Mine honestly feels like I could have had a brain injury.

 

[MichaelTheAnhedonic]

I have a blank mind and my SPECT scan showed lower activity at the Right Frontal Lobe and deficits in left brain hemisphere.

 

[azteca2]

Michael I'm not sure if I remember correctly but weren't you diagnosed with a cerebellar disorder?

 

[MichaelTheAnhedonic]

Nope. Not diagnosed yet.