Those are very, exceptionally low doses of Celexa and Zoloft. 25mg is the lowest dose recommended of Zoloft, and 5 mg Celexa is below the lowest recommended dose of 10mg. Are you getting a doctor to prescribe these, or are you taking these from the Internet or a friend? I wouldnt add a third to this combo. While they all have a different chemical structure, they simply do the same thing. Celexa affects serotonin, Zoloft affects serotonin, and Effexor affects serotonin, norepinephrine, and dopamine. You're asking for awful side affects or worse yet, serotonin syndrome. For instance, you cant combine Straterra and Wellbutrin. The way their metabolites and their affect on neurotransmitters work, they will actually be competing against each other. While they both act on norepinephrine, just like Zoloft and Celexa both act on serotonin, they will actually begin "competing" for receptors, and the side effects are not pretty. You're basically overloading your brain with norepinephrine and chemical breakdowns of the pills. So stick with one med, and get it to a proper dose - but with a doctor's help. My personal favorite is Celexa. Its been known to help DP quite a bit, and it has the best side effect profile of ANY antidepressant, hands down. Effexor has been known to help DP as well, but its side effects can be devastating, as well as its withdrawal. My two cents.