Hi,
I've also been diagnosed with DP. Had very similar effects to medication as the first person in this thread. Anxiety to all SSRIs that I've tried and Effexor. Also tried Remeron, which was hugely sedating, Serzone and trazodone.
I tried desipramine recently, and it was horrible. I did have a few minutes a week or so ago when I came out of my dissociative state. Then again a minute or so, a few hours later.
I took it only up to 50 mgs before it became unbearable. Most notably, incredible over-stimulation, loss of sleep and, loss of sense of time, and totally weird sleeping paterns. So, I've come off of it
I just tried Clomipramine (Anafranil). The norepinephrine effects where just as prevalent as with the desipramine. Incidently, desipramine works almost exclusively on norepinephrine (so that's where the effects come from).
My psych said that some patients react to SSRIs with increased anxiety. It makes me feel 'fried'.
I also got the 'fried' feeling from amino acid supplements like Tryptophan.
For over a year I had written off all anti-depressants because of my experiences with them. Then I remembered that the first anti-depressant that I was on was Serzone (nefazodone), which gave me more access to my feelings and didn't come with the anxiety of the SSRIs and other anti-depressants, (at least initially - I can't remember if it came later). In fact, I remember I was constantly feeling like I needed to cry, which is a good thing for those of us with disociative disorders.
Anyhow, just a heads up. I live in Canada where nefazodone is not approved for medical use - because of very rare liver failure.
If you try nefazodone, please post about it, no matter if it works or not. Also, please put nefazodone or Serzone in the title.
Women might also want to try trazodone. (Men can't because of painful and prolonged erections.)
Michael
I've also been diagnosed with DP. Had very similar effects to medication as the first person in this thread. Anxiety to all SSRIs that I've tried and Effexor. Also tried Remeron, which was hugely sedating, Serzone and trazodone.
I tried desipramine recently, and it was horrible. I did have a few minutes a week or so ago when I came out of my dissociative state. Then again a minute or so, a few hours later.
I took it only up to 50 mgs before it became unbearable. Most notably, incredible over-stimulation, loss of sleep and, loss of sense of time, and totally weird sleeping paterns. So, I've come off of it
I just tried Clomipramine (Anafranil). The norepinephrine effects where just as prevalent as with the desipramine. Incidently, desipramine works almost exclusively on norepinephrine (so that's where the effects come from).
My psych said that some patients react to SSRIs with increased anxiety. It makes me feel 'fried'.
I also got the 'fried' feeling from amino acid supplements like Tryptophan.
For over a year I had written off all anti-depressants because of my experiences with them. Then I remembered that the first anti-depressant that I was on was Serzone (nefazodone), which gave me more access to my feelings and didn't come with the anxiety of the SSRIs and other anti-depressants, (at least initially - I can't remember if it came later). In fact, I remember I was constantly feeling like I needed to cry, which is a good thing for those of us with disociative disorders.
Anyhow, just a heads up. I live in Canada where nefazodone is not approved for medical use - because of very rare liver failure.
If you try nefazodone, please post about it, no matter if it works or not. Also, please put nefazodone or Serzone in the title.
Women might also want to try trazodone. (Men can't because of painful and prolonged erections.)
Michael
