I have tried a few of these now and am confused about my reaction to them. Can anyone shine a light on what might be happening? Very small doses seem to adversely affect me. I've tried almost all the ssris and can't tolerate them mainly because they cause me extreme insomnia. Even the more supposedly sedating ones like Paroxetine cause me very severe insomnia, at a low dose of 10mg. I've been on Paroxetine 10mg for nearly 4 weeks now and the insomnia is so debilitating that the doctor has told me to come off it. Is this insomnia a sign that the medication is actually activating my brain and bringing me out of a deep depression or is it a sign that I don't need an antidepressant at all? Fluoxetine, Venlaxafine and Sertraline all have the same effects on me - really bad insomnia and agitation that doesn't pass even after many weeks and months on them. I didn't have this effect on Citalopram but that drug just made me emotionless and sluggish (after a good while of being on it - 3 months). I've tried Mirtazipine and had adverse side effects to that. I don't want to try antipsychotics. After trying these drugs, my GP is saying I shouldn't be on anything as nothing agrees with me. However, I haven't tried any of the older antidepressants so am confused about this. In general, I would say I have a moderate depression and severe anxiety with DP. I definitely need to be on something.