Hello! Im on anafranil/clomipramine since one week back. I read on wikipedia that it is a antagonist (blocker right?!) On 5HT2a and 5HT2c. Then i read on another sight that activating these two has the opposite effect of what ive read anafranil is prescribed for. Depression,anxiety, chronic fatigue can become worse by activating these two. And the receptor that should be activated is 5HT1a. So, isnt it bad that anafranil blocks these two receptors, or does it mean that its good? Please answer if u know!