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i just read a medical question/answer in the guardian weekend mag. someone on effexor asked for an alternative. the answer said that effexor affects seratonin(mood) and noradrenalin(motivation). for seratonin supplement tryptophan by taking 5htp(100mg a day). for noradrenaline take amino acid tyrosine(2000mg a day). omega 3 and b vits may also help. i've never heard of tyrosine