I used to drink quite a bit on Zoloft. Eventually, i just stopped the drug and got better. I don't know if it made it better or worse as i never really had a control experiment to base it on. But i think it's quite safe to drink while taking it, although you might find it makes you feel a little nauseated. But i also find that if you drink enough, you won't notice the nausea so much. :wink: