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comfortably numb

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#196169 Issue with any medication

Posted by comfortably numb on 11 July 2010 - 11:07 AM

Both nyquil and zyrtec contain anti-histamines. Different formulations of nyquil contain different medications but they all contain doxylamine succinate as the anti-histamine. It is one of the drowsy anti-histamines There are other things in nyquil such as pseudoephedrine a decongestant that is a shitty stimulant that is bad news for alot of people with dp/dr as it causes anxiety that is sometimes rather severe. Other ingrediants are acetaminophen (shouldnt have any effect), phenylephrine is a decongestant that is pretty much useless that was put in to replace pseudoephedrine and is also a shitty stimulant though less likely to cause anxiety and other side effects then pseudoephedrine and alcohol is in most formulations.

Zyrtec is certirizine which is a second generation anti-histamine that only causes very mild drowsiness due to only crossing the blood brain barrier very slightly. But maybe these anti-histamines just don't agree with you? Plus the meds commonly given for dp/dr act differently then anti-histamines. Although certain anti-psychotics seroquel for one and certain anti-depressants remeron (mirtazapine) for one are strong H1 antagonists thus they do have strong anti-histiminic side effects. Drugs such as the benzodiazepines, anti-convulsants, ssri's and many more don't act as anti-histamines at all.


#196168 Medications = drugs

Posted by comfortably numb on 11 July 2010 - 09:38 AM

Okay old post but i had to chime in on this one. All drugs are chemicals but not all chemicals are drugs. Most do nothing or very little to the CNS.

Also some of the drugs that cause dp/dr in some people can treat it in others. So it's not a one size fits all type of thing when it comes to this. Saying that all drugs are bad is just stupid and ignorant.


#196164 Ultram / Tramadol

Posted by comfortably numb on 11 July 2010 - 08:40 AM

Okay first off tramadol which is the opioid in ultram, ultracet, tridural, ralivia and others (i just listed off some north american brand names) is not a typical opioid such as codeine, hydrocodone, oxycodone, morphine, hydromorphone, diamorphine aka heroin or fentanyl. It has very weak mu opioid receptor binding but it is also a serotonin norepinephrine reuptake inhibitor. So it's a SNRI like effexor or cymbalta with a tiny bit of opioid effects.

This means it has potential in treatng depression (it's sometimes prescribed off label for this) but it also means your going to get alot of the same side effects as you do with drugs like effexor. Though i never found it to be as shitty as effexor but the longest ive taken tramadol for is a week tops and even then i might have taken a day off i think. You also have a good chance that you're going to get hit with WORSE withdrawals then coming off oxycodone, morphine, etc since you are going to be going through SNRI withdrawal as well as opioid withdrawal. Though the opioid withdrawal part of it should be milder then coming off oxy, morphine or heroin but this is just a theory based on tramadols mild opioid effects.

The use of opiates/opioids (i don't use the term narcotics as it's not specific to opiates and in case anyone is wondering opiates usually refer to naturally occuring or semi synthetic drugs with opium like effects while opioids refer to fully synthetic drugs with opium like effects) in the treatment of depression or mental disorders in general is far from new. They have been used to treat various mental illnesses as far back as anyone recognized that there was anything wrong with anyone in the head or as we call it today the brain. Most opiates/opioids have some anti-depressant effects since they cause euphoria and a sense of well being. God knows i self medicated enough with them over a long ass period of time to treat my bipolar disorder. The results where umm mixed to say the least :unsure2: .

Tramadol could worsen dp/dr more so then your regular old opiates like good ol morphine due to it's SNRI effects. It made me feel really weird, kinda spaced out and nauseous. It also worsened my bipolar disorder due to the SNRI properties as SNRI's or any anti-depressant that touches serotonin make me completely batshit crazy like they do with many people with bipolar disorder. So although it's not my most hated opioid (propoxyphene the stuff in darvon and darvocet takes the prize for that) but it's down there on my list of opioids that i have a liking for. It does absolutly nothing to help my pain at all and it worsens my bipolar disorder so yeah not the drug for me really. Also i can't get high off the shit at all.

A few words of caution about tramadol i thought id go over. Although it's a very hit or miss drug where some people love it and others hate it with a passion the ones that love it seem to REALLY love it. A few people i know that are addicted to it are fanatical about it to the point where they abuse the living shit out of their tramadol prescription and run out then go spend all their cash ordering it off the internet. It must be hard to run out of tramadol and not be able to get your doctor to write you another script since here in canada many doctors don't think twice about giving out loads of the sample packs to you that whatever drug company has pushed on them for no matter what type or severity of pain you have. The drug reps must tell doctors that tramadol is like morphine in it's painkilling abilities with none of the addiction because many of them seem to believe it. Also since tramadol is not a controlled substance doctors don't have to worry about getting in any trouble. So yes it can be rather addictive and i have even heard a few people say that kicking heroin or fentanyl was easier. Yikes.

Also there is the seizure risk associated with tramadol especially when you get to the 400mg a day mark. So if you are prone to seizures at all or are tapering off a benzodiazepine or a drug from any class of anti-convulsants or have just stopped one this drug is not for you. Also if you are on any drugs that also lower the seizure threshold such as wellbutrin (bupropion), most anti-psychotics both typical and atypical, tricyclic anti-depressants as well as many other drugs that i can't be bothered to list here or can't remember off the top of my head tramadol may not be for you. It lowers the seizure threshold especially above the 400mg a day mark but this does not stop some people from going over the 400mg a day mark and risking tonic clonic seizures.

There is also the risk of serotonin syndrome when taken with other serotonic drugs such as SSRI's, SNRI's, most tricyclics, MAOI's (amoung the other risks of taking it with MAOI's), atypical anti-depressants such as trazadone, mirtazapine, etc, dextromethorphan and i think MDMA as well. Im not sure about the interactions with MDMA but i certainly wouldnt mix the 2.

Im not saying this is a bad drug but it's just not for me. It may help some people with dp/dr but like with any other drug it will make other people worse. Thats just the luck of the draw really and not taking that risk means not trying any medications which could very well mean a lifetime of untreated dp/dr. So this drug like any other has it's risks and also has it's benefits.

Another opioid that is used off label for treating depression is buprenorphine. It's the opioid in suboxone and subutex that is used in treating opioid addiction and is quickly becoming the drug of choice in opioid mateniance programs atleast in the US. They are the same drug except suboxone has naloxone in it and subutex does not so it gives doctors the idea that it can't be abused IV. When in fact buprenorphine has a strong enough binding affinity to the mu receptor that it overrides the naloxone thus suboxone is fucking pointless except for getting doctors to write out scripts easier.

Im not telling anyone not to use tramadol to treat dp/dr, depression or anything else i just believe in people making informed decisions before they go taking any medications.

It seems like it would just be like something that would sedate the living hell out of you. I dunno. And like a replacement for Benzos.


I as well as many other people i know get a odd stimulant effect from it not sedation but many people do get a sedative effect from it. Also tramadol is nothing like benzodiazepines much less a replacement for them. I never found any opiate/opioid to be as good at treating my dp/dr, brain fog and anxiety as clonazepam is.

Wow that was long :blink: . Props to anyone that read all that!


#195179 Anyone with medical knowledge? Felt like I'm rushing for 6 weeks =/

Posted by comfortably numb on 03 July 2010 - 03:48 PM

Don't take unknown substances it's not a good rule. This sounds like it was brought on by a panic attack and there is no drug that lasts anywhere near that long.

I OD'd on pot brownies


No you didnt you just ate too many of them. You can't actually OD on cannabis it's impossible. You might get too stoned to the point where you start to freak but no you won't OD. Nothing that chilling in a quiet room listening to music wouldnt help or if needed a fast acting benzodiazepine.
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#191274 Anastesia, SOMEONE HELP

Posted by comfortably numb on 04 June 2010 - 03:08 PM

You have nothing to worry about. Anesthesiologists know their stuff and are very used to dealing with all sorts of people. Many people are on high doses of benzodiazepines and opiates at the same time and get surgery done everyday so they are used to seing people with high tolerances to the drugs they use.

For getting a colonoscopy you would just be given midazolam more then likely or sometimes fentanyl. I think they very rarely use fentanyl though and just go with straight midazolam. You arent always knocked out but you won't remember most of what happened and you usually won't be in pain because you are so messed up.

For the operation you are getting they will knock you out though. Probably with a strong opioid suck as fentanyl with midazolam and a knock out anesthic. Sorry im too lazy too look up the spelling of them right now :sleep: . But don't worry theyve seen people with alot higher tolerances then you and those people get put under.

Don't worry about it but make sure they know what meds your on and what dose as well.


#154398 whats the difference between alcohol and benzos

Posted by comfortably numb on 27 February 2009 - 05:34 PM

Don't drink on xanax or any other benzodiazepine. It is generally a very bad idea. Benzodiazepines are not lethal on their own but they are when mixed with alcohol in high enough dose and it might not take much. Xanax is also one of the worst benzos to mix with booze since it causes really bad blackouts on it's own in high doses let alone mixed with alcohol. In fact almost every story involving benzos that ive heard where someone did something stupid involved xanax.

A valium with a beer or 2 won't hurt you but benzos and alcohol are just generally not a good mix especially if you take a recreational dose of either. You can always have a blackout and forget how many pills you took and take more. This happens quite abit in people who mix alcohol and benzos.

Alcohol does not help mental problems at all trust me on that. I self medicated with alcohol for years and all it did was mess me up way more. Get some kind of help for your problems instead of trying to drink them away.


#100646 zoloft withdrawal

Posted by comfortably numb on 06 June 2007 - 04:24 PM

Never been on zoloft or any other ssri but i was on effexor which is a snri and has the same withdrawal symptoms only worse. Effexor is considered to have about the worst withdrawal out of any psych med on the market actually.

Those brain zaps are godawful the absolute worst withdrawal symptom ive experienced from any drug. But taking benadryl or dimenhydrinate does help with those for some stupid reason so you could try that. I also had severe mood swings coming off it even worse then when i was on the stuff lol. I also had insomnia, nausea, vertigo and on a few occasions vomiting.

But your coming off zoloft not effexor so you shouldnt have nearly as hard of a time as i did even though i was on it for less then 2 month's at a low dose. I also dropped it cold turkey which was very stupid but i didnt know it could produce dependence at the time.

All in all id say that if you taper you shouldnt have too much trouble. If it does get really bad you could also try the prozac taper. Prozac has a very long half life of about a week i think so that's why some people switch from another ssri to that to taper off. The longer the half life the easier it is to taper off.

Oddly enough benzos like klonopin are sometimes used to help with the withdrawal symptoms of ssri's. I think i used valium after the withdrawals kicked in really bad. I remember that it helped me sleep, calmed me down and helped with the brain shocks a little bit. I also smoked alot of weed and that helped alot to keep me sane during that hell. But i wouldnt recomend that to you as i don't know how you react to it.


#80536 Please don't laugh... DP induced by cold meds?

Posted by comfortably numb on 08 November 2006 - 06:06 PM

The anti-histamine in nyquil and benadryl which is diphenhydramine (i think some brand's of nyquil have doxylamine which is similar to diphenhydramine) are big trigger's for dp/dr.

These drug's are dp/dr in a bottle for me. They almost always bring out dp/dr, brain fog and anxiety in me. They turn me into a zombie yet im still anxious.

So ya the cold med's definatly played a part in your dp/dr. Id bet money on it especially if you took double the dose.

The wellbutrin probley is playing a part as well. Wellbutrin is a stimulating anti-depressant made for the type of depression where people oversleep and have no energy. One of it's main side effect's is increased anxiety.

Also wellbutrin can mix bad with cold medicines especially if either one of them had pseudoephedrine as a decongestant. Pseudoephedrine is also a stimulant and can give some people horrible anxiety. I cant tolerate it at all.