I think my DP is secondary to my high adrenaline and high cortisol, anyone else had these tests? anyone relate?
TLDR at the bottom. Thanks in advance. 28, Male, 182cm, 18 stone (was 12 previously), White, Duration 4 years/5,
Current medications; Xanax, Doxazosin, Escoltapram (Tried 30 + mediations listed below)
Smoke lightly, drink to crash this wired existence once a week.
Complaint: Stimulated beyond belief 24/7 until after many days no sleep and stimulation, I crash. Sweating, tremors, fatigue, weight gain, dilated pupils, adrenaline rushes, bladder shrinkage, depersonalization, anxiety, depression, etc.
The above makes sense, as my Cortisol and Adrenaline is high, but WHY? Endo's and physiatrist can't work it out either. They have both said anxiety disorder would not make the levels I have.
I've spent 4 years, many thousands and free health care, everyone agrees it's extreme (been hospitalised etc) but no one on earth seems to know what it is. I've had had EEG's, MRI's, CT's, Endo's, P Docs, Cardiologist, GP's.
Ruled out: Phaeochromocytoma, Cushing's, Thyroid Glands (CT + Bloods), Adrenaline (CT + Bloods), Bipolar, POTS (tilt test etc), Autoimmune disorders (Bloods etc). Amongst many other things.
Now, after 4 years what we know on paper is my adrenaline is high, "Plasma adrenaline – HIGH - rose to 568 above the normal range of 0-459 No nocturnal fall – On the 24-hr BP/HR autonomic profiles mean daytime BP was 133/92 and HR 88, without the expected nocturnal fall. Worse when standing, The BP was elevated at times when he was polysymptomatic, the highest being 162/101 when standing. No evidence of autonomic failure".
We also know that every time I do a urine test for Cortisol it is above the range slightly.
But we can't pin this to anything, for instance as well as being stimulated I am now allergic to pseudoephedrine and ADHD stimulants, which they tried amongst many other things to see how I'd react. One doctor said I seem "Angernegic" but couldn't label me with any condition, my own GP is now reading about Adrenaline Fatigue, as he said the other something like "I never believed it was a thing until I've spent 2 years on your case".
Waiting on Spit test this upcoming week for:
Lithium (Highest dose), Melatonin, Depakote, Quetiapine (50 to 800mg,), Lamotrigine (couldn’t tolerate), Olanzapine 20mg, Buspirone /Promethazine/Buspirone/ Diphenhydramine (makes my heart jump) Mirtazapine, Zopliclones (15mg), Zoloft.
Elvanse, Backlofen, Phuesdephridrine (Sodafed), Guanfacine, Coffee, ClonidineDescriptio Clonidine
Slightly helpful: Propranolol 80mg for shakes, Clonazepam
Sometimes lower stimulation for a few hours;
High Corisol and Adrenaline in urine and blood respectively, what could I have that isn't ruled out (Phaeochromocytoma, Cushing's, Thyroid Glands (CT + Bloods), Adrenaline (CT + Bloods), Bipolar, POTS (tilt test etc), Autoimmune disorders (Bloods etc).