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Will implanting naltrexone help


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#13 Messirocks

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Posted 26 July 2019 - 06:38 AM

I currently take 150 mg

#14 Messirocks

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Posted 26 July 2019 - 06:38 AM

* lamotrigine

#15 Mayer-Gross

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Posted 26 July 2019 - 08:10 AM

U really don't know anything idiot

 

 

Lamotrigine didn't help u that's why u r crying 

projections. 



#16 Messirocks

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Posted 26 July 2019 - 09:00 AM

Idiot Mayer gross

#17 Mayer-Gross

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Posted 01 August 2019 - 09:44 PM

Ding-dong,-Messirocks.



#18 Trith

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Posted 03 January 2020 - 11:35 AM

No, you will spam this forum with that subject as it shouldn´t have any interest for anyone. Naltrexone has a very low affinity for the kappa opioid receptor and you need a dose of 150-200.mg to feel partiel response to it. Very few can tolerate it and very few afford it. Everything in relation to naltrexone and other drugs that are antagonistic for the opioid system can be found in previous debates here. You have nothing relevant to come with and that is not your intention either. 

 

But there is that study, where they tried low doses of naltrexone between 2 and 6 mg daily.

 

https://www.ncbi.nlm...pubmed/25421416

 

Over 15 patients, 11 saw an improvement and 7 a long lasting improvement. In the abstract they don't talk about using a control group though.



#19 Mayer-Gross

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Posted 03 January 2020 - 12:55 PM

But there is that study, where they tried low doses of naltrexone between 2 and 6 mg daily.

 

https://www.ncbi.nlm...pubmed/25421416

 

Over 15 patients, 11 saw an improvement and 7 a long lasting improvement. In the abstract they don't talk about using a control group though.

 

Those people do not suffer from depersonlisation disorder but complex dissociation . The full text in german i  here;https://www.research...iative_symptoms

 

 

Naltrexone, naloxone and buprenophine has been tried in much higher doses by many. A dose of 100.mg of naltrexone is typical for some to fell a small reduction in symptoms like 15-20%. As it stands one can say that opiopate antagonist might take some of the symptoms particularly numbing.  



#20 freewilly

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Posted 03 January 2020 - 02:24 PM

At kings college they have run trials with no success as far as I know. Neither with TMS..



#21 Mayer-Gross

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Posted 03 January 2020 - 02:55 PM

At kings college they have run trials with no success as far as I know. Neither with TMS..

 

There has been no trails at Kings College with a opiopate antagonist. There has been a russian trial with naloxone infusion and a trial done at the former research unit in the US under Daphne Simeon .She stills tries on the private patients she have in a dose of 50-100.mg. The video blogger "DPD Diaries" who has been in a CBT session at the unit (that has done no research since 2016 and only sees patients) with no results was put on naltrexone as a trial by a psychiatrist recently.

 

You claim that rTMS didn't have any effect in also false. They did two trials a the right VLPFC with rTMS and there was a reduction on avenge of 44% in symptoms with 6.session. They wrote that;"Data presented in this case series indicate that 1 Hz rTMS to the right VLPFC may be a potential treatment option for DPD, which has previously proved difficult to treat with pharmacotherapy. Six out of seven participants showed over 25% improvement in symptoms, two over 50%. One participant did not respond to treatment. may act via biological mechanisms different to that of psychotropic medications and as such make it a potentially new treatment method for the disorder.".....The potential of rTMS as a treatment option for DPD requires further study in the form of a controlled trial of multiple sessions of rTMS. If further sham-controlled research proves positive, rTMS may be judged an appropriate intervention or adjunct to other interventions e.g. antidepressants. Combining treatment studies with investigations of mechanisms using neurophysiological and neuroimaging techniques for example would also lead to rapid advances in the field"

 

https://www.ncbi.nlm...les/PMC4906152/

They have had no funding since 2016 for larger trials or research . Most researchers have left the unit and Anthony David who was head of unit has shifted to a professorship at University College London and I follow him on twitter and i posted some things related to the right VLPFC and social exclusion and he replied the right VLPFC had a role as a target in depersonalisation. So, he still believes in rTMS and the right VLPFC. 



#22 curiousmind

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Posted 03 January 2020 - 03:45 PM

Those people do not suffer from depersonlisation disorder but complex dissociation . The full text in german i  here;https://www.research...iative_symptoms

 

 

Naltrexone, naloxone and buprenophine has been tried in much higher doses by many. A dose of 100.mg of naltrexone is typical for some to fell a small reduction in symptoms like 15-20%. As it stands one can say that opiopate antagonist might take some of the symptoms particularly numbing.  

 

what is complex dissociation, and how can it be differentiated from dpdr? Is "complex dissociation" a legitimate disorder? 



#23 Mayer-Gross

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Posted 03 January 2020 - 03:53 PM

what is complex dissociation, and how can it be differentiated from dpdr? Is "complex dissociation" a legitimate disorder? 

 

You can look complex dissociation up. It is not related to depersonalisation. In this text about depersonalisation there is a significant difference between the two; 
 

"Both ICD10 and DSMIV betray uncertainty as to the nosological status of depersonalisation: in the former, it is included under the vague heading of other neurotic disorders, whereas in the latter it is listed under dissociative disorders, an equally problematic classification, as the hallmark of true dissociation is a lack of subjective awareness of change. By contrast, sufferers from depersonalisation are all too aware of a disturbing change in their experience of themselves and/or their surroundings – indeed, in the primary disorder, this awareness of change is the very essence of the presenting complaint. Other ways in which depersonalisation differs from dissociative disorders are explored at length in Hunter et al (2003)."

 

https://pdfs.semanti...6cc61c43d27.pdf



#24 curiousmind

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Posted 03 January 2020 - 06:20 PM

https://www.ncbi.nlm...les/PMC4906152/

They have had no funding since 2016 for larger trials or research . Most researchers have left the unit and Anthony David who was head of unit has shifted to a professorship at University College London and I follow him on twitter and i posted some things related to the right VLPFC and social exclusion and he replied the right VLPFC had a role as a target in depersonalisation. So, he still believes in rTMS and the right VLPFC. 

:( so whats next, who will be/are the current researchers, and do you know where research is currently being conducted? I heard Sierra also left the KCL research unit and no longer studies or treats dpd...






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