Imipramine (analogue of clomipramine)
Posted 29 January 2019 - 07:37 AM
Have been more productive recently and perhaps I am more aware of my surroundings as if I am more conscious if that makes sense. Which in turn makes me less anxious. Perhaps my DP has improved but not my DR. I feel more connected as if I am more aware of multiple senses as well. Seemed like before I could only keep track of one thing.
I would add I started a Cbd Vape which I think has helped my sleep and I dream a lot more. My theory is that dreaming helps you process emotions. All of them are fear based (so anxiety) where I am running or hiding from something/one.
This sounds like the road to recovery but I would also say the changes have been minor. But I wouldn't expect an overnight change and am optimistic about this medication more than any other. No emgative side effects to report. Increased appetite may be an issue for most people but I am underweight and don't have a good appetite so this is a good thing.
I am in the Dr's office now and writing this but am aware of what's being said around me more. I would be anxious before that I was so zoned out I would miss my name being called. So these are small but significant changes for me... hoping it continues with improved sleep. I would also add I have hemp leaf tea with green tea to mask the flavour a bit. Leaves do supposedly have CBD in and other cannabinoids which helps me get a good dose daily
Posted 04 February 2019 - 03:46 AM
Good to hear small steps to recovery!
Did it do something for your tinnitus and the crackling of your ears when dry swallowing?
I'm also curious what your DR is like.. like how does your world look? because it's the main issue for me besides a lot of physical symptoms.
And in all those years have you ever tried something that did a thing with your DR ? I tried coQ10 last week and it sure as hell made my DR worse for a little time, i felt really weird on it i can't even explain.. I'm going to try NAC and Glycine next week, i'll let you know how that goes.
- Broken likes this
Posted 04 February 2019 - 07:06 AM
Weirdly my tinnitus changed for a moment last night. As with everything with DPDR it is hard to explain, but it felt like the ringing from each ear almost moved towards each other and stopped and I could hear more of what was happening around me. As well as that the DR seemed to improve for a moment. Generally things are a lot better and socialising last night was easier. Unfortunately I am very sick today with a stomach bug so that may well stall things as I probably threw up some medication
My DR is the typical 2D unreality feeling, almost like before when I had a hangover and hadnt slept. Just this groggy brainfog. It doesn't bother me really, it's mainly the hearing issues and cognitive issues. Last night my eyes really hurt and I have noticed that my pupils are generally larger than usual. Could be a sign of the imipramine affecting my HPA axis and calming my nervous system. So hopefully making my eyes/ears less hypervigilent and more capable of noticing what is happening socially rather than zoning out or being distracted by noises.
My DR has faded momentarily with alcohol and lions mane mushroom but that seemed to stop. The imipramine is helping slightly but it will take time for my amygdala etc to calm down and then other brain regions getting used to being active again. But I am positive about the progress so far
- DerealizedDutchie likes this
Posted 05 February 2019 - 06:46 PM
did imipramine help your dp?
Yeah, but at that time I wasn't DP'd 24/7. Amitryptyline got me out of that, but it's a very strong drug with STRONG sedative f/x. I was in college at the time, and people were coming up to me and asking if I needed help! LOL!
Imipramine was used by the Panic Disorder research program I was involved in at Columbia University in crazy large doses. When I told the doctor in charge that I once took 100mgs of Amitryptyline, he said, "That's nothing. We use hundreds of mgs., in some cases over a thousand!"
I thought the guy was nuts, but that's what they did. They went up to 350mgs. of imipramine before it blocked my DP panic attacks. I was skinny when I entered the study, and I wound up putting on 30lbs., so that's another difficult side effect.
- Broken likes this
Posted 05 February 2019 - 07:03 PM
I think I will wait a further 2 months and then reassess if things haven't progressed. I am hopeful so far
Posted 26 February 2019 - 07:23 AM
Thought I would update this as I know I have found it frustrating seeing promising threads that suddenly end.
I am now about 2 and a half months into taking Imipramine at 100mg with a CBD vape 3x a day. Things seem to be slowly improving, but it is hard to say. My appetite is better but oddly I haven't put on any weight (actually lost a small amount). My focus, optimism, general mood and sleep have all improved. I dream regularly, every night in fact, which was a rarity before medication.
I do think dreams are significant to process emotions and consolidate memories, as well as rest and regeneration/neurogenesis etc as dreaming is the last sleep cycle before the cycle starts again. I have been applying for jobs which has been the first time in years really and have an interview this week. This is a big step for me. Socialising is still the difficult thing but I have been making more effort to engage and seem more aware of what is happening around me.
Overall I am still optimistic. I think the 4-6 week thing for anti depressants to 'work' doesn't apply to me here. You could almost see it as years and years of untreated depression so I am expecting 3-6 months to see results. But clomipramine is one of the drugs that is said to be most effective for DPD and depersonalization disorder is even on the wikipedia page under 'medical uses', so really if your GP knows his salt this would be the first dug he puts you on. Imipramine/clomipramine also treat major depressive disorder which I suspect I have with anxiety and complex PTSD from a traumatic childhood.
I expect improvement to be minor and slow as I am essentially growing back connections to a damaged brain. I mean damaged as in from trauma and the brain is extremely plastic and can heal all kinds of physical/mental/emotional scars.
A side note on CBD, if you have anxiety/tension or difficulty sleeping I would strongly recommend it. I am going to try a full spectrum vape next that will have CBD as well as a host of other cannabinoids. Supposedly they work together to form 'the entourage effect' which makes their effects more strongly felt, and really is how nature intended it. Advances in medicine are amazing but it wants binary answers to complex things like 'why does cannabis work' and then narrows it down to THC and CBD.
There are loads of other cannabinoids as well CBC/CBG etc that are being found to have incredible effects on the bod as well. So I am looking forward to trying a full spectrum sample. Anyway, I will update here in a few weeks/when things have changed further. I am following the thread so will get notifications if anyone has any questions
Posted 31 March 2019 - 09:34 AM
Hey broken, I've been following this thread and have been wondering if any significant changes have happened since you last checked in? I'm thinking of trying imipramine as well.
Posted 31 March 2019 - 02:28 PM
I have had no significant changes tbh since I last posted. Perhaps mood is generally better all considered but other than that nothing really. Still some people say that with meds you can wake up one day and its gone. I am going to keep taking it a few more months then will consider coming off it if nothing has improved. Will keep you updated
It is worth you trying though as many have had a good experience with it. Let us know how you get on
Posted 14 July 2020 - 05:56 PM
Posted 14 July 2020 - 06:25 PM
Did nothing for me tbh, I thought it was helping sleep but gave nothing but bad side effects so I discontinued... supposedly there is a difference between imipramine and clomipramine but I could only get imipramine in the uk
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