The above was a tiny sample size but showed one patient responded to desipramine and one to clomipramine (out of 8 total). Also considering that 2 patients discontinued due to side effects this is quite strong... I can't see the dosage they were given, but hope they were tapered onto it like I am- 25mg a day at first noting side effects and then up to 50mg when they subside. I had a bit of nausea and insomnia the first few days but my body seems to have adapted. I am a but more fatigued than usual and sleep more but perhaps this is what my body needs
Don't know why I just found this, it's a shame there are no large studies on medication with DPD. King's college London really seem to be pushing the psychotherapy agenda at the moment. It is something that can help some but their research seems more based on this recently. I guess if you can have an 'effective therapy' you can charge obscene amounts (which they do). I would imagine that therapy of any kind would be thorough and take years.
Anyway, side effects are completely tolerable to me at the moment and am on 50mg. Plan to stay on that dose for a couple of weeks now.