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#49 TDX

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Posted 26 October 2015 - 09:04 PM

 

 

Are you suggesting that the affinity for KOR is too weak to have an effect at those doses?

Yes.

 

 

 

Nobody ever seems to talk about MOR having a role in dissociative phenomena so this is interesting if true.

In this study only people with very severe childhood trauma participated. Maybe this subgroup responds to MOR-blockade.



#50 luctor et emergo

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Posted 27 October 2015 - 06:40 AM

Nalmefene dose is now at 36.16 mg/d. In 30 minutes EMDR session. The goal of the therapist is to crack my firewall and gain acces to emotions. As Nalmefene was somewhat succesfully used to treat PTSD war veterans... the numb feeling. There is a chance.
Thanks for bumping this thread!

#51 luctor et emergo

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Posted 27 October 2015 - 08:46 AM

Ventricle size. Yes that was the one noticable discovery on my MRI which I underwent in 2006, age 25. The MRI was performed because I was afraid of neurological damage after 6 years of cannabis, 8 years of alcohol, 4 years of cocaine, 1 time mushrooms and occasional xtc use. My dpd, drd symptons became noticable at age 18.

"somewhat enlarged ventricels compaired to people aged 25 to 30 years."

#52 Zed

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Posted 01 November 2015 - 02:56 PM

I think this thread needs to be renamed to 'The Thread of Denial'. 

 

BTW PSTD is a little more than 'the numb feeling'.



#53 keat0

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Posted 01 November 2015 - 04:43 PM

'increased synaptic dopamine such as the amphetamines, methylphenidate, pemoline, bupropion, etc. seemed to be beneficial for depersonalization.1'

 

From the case report of methlphendidate. 

 

+1. When I was taking it I thought it had cured me. But then I started getting bad (I think hypertensive) headaches as well as tremors from the ritalin. I had to stop. I took a genomind test and found out that I have a mutation in an enzyme that breaks down dopamine in the PFC and mine doesn't function well so I have higher PFC dopamine. 

 

Found that interesting and also interesting that ritalin was so helpful. 

 

Also, can you expand on your commentary on HPA? 

 

I also suggest you check out tineptine as it related to hippocampal atrophy as well as semax. 



#54 luctor et emergo

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Posted 21 November 2015 - 03:47 PM

Interesting model. Is there more in-depth information on the neurobiological factors?

Glutamate inhibitors and DOR, MOR, KOR antagonists seem to be effective on dpd, drd according to this model?



#55 hidden

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Posted 12 December 2015 - 04:51 AM

http://www.nature.co...ature11306.html



#56 hidden

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Posted 12 December 2015 - 05:11 AM

webmd_rf_photo_of_mri_brain_scans.jpg



#57 hidden

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Posted 12 December 2015 - 05:16 AM

https://en.wikipedia.org/wiki/NSI-189

 

The place that gets taxed a lot is the hippocampus.   Stops sending negative feedback to stop CRF.   It has also been implicated in many other mental illnesses.    Of course with the dissociation, it is those aspertame receptors that also receive Glutamate. 

 

 

Psst!  This is my thread



#58 hidden

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Posted 12 December 2015 - 01:42 PM

Look at PCP models to understand dissociation.  

 

zombie_model_and_pilgrim_by_ebxinc-d31op



#59 hidden

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Posted 30 December 2015 - 01:05 PM

I found this interesting about an older drug that I have talked about in the past, but which keeps coming up in some researches I am doing.

The drug is Minipress (prazosin).  

 

 

 

http://www.jwatch.or...op-stories-2013



#60 hidden

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Posted 30 December 2015 - 01:09 PM

I just realized this is from the New England Journal of Medicine.  I think we can trust this reference.  

[Also:  I like this doctor I think....Click on his name and view his other studies perhaps]. 






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