Posted 29 August 2020 - 12:41 AM
Posted 29 August 2020 - 04:11 AM
This is just a continuation of existing research. There are done operations with deep brain stimulators into the brain in a very limited trails of disorders in people highly refractory to existing treatments. If you take depression it will be patients who have tried everything including ECT. This group of patients have often been brain scanned to find areas in the brain active that makes them refractory to treatment. So, they are already a subgroup within depression as they have a kind of depression with this special brain activity. So, the operation will likely not work in most people in depression but in only in this subgroup. The operation is typically done in an area called Brodmann area 25 or subgenual cingulate that is found overactive in many with refractory depression. Because the treatment/operation is very expensive you have to go though many examinations with likely many testing with functional scanners to make sure that this area is active in your case. The problem with depersonalization is we do not know such an area in the brain where we for sure can say that there is the core for depersonalization and we can intervene there and stimulate this area. The idea of intervening with operations in depression dates back some decades and the foundation for depression is this trail from 2005.
rTMS is a little related to this kind of thinking. The intervention is not so irreversible and expensive but is based on the same kind of thinking. To stimulate or inhibit an area in the brain that is found abnormally active. Brodmann area 25 is very deep in the brain for rTMS to stimulate directly. Until 2017 rTMS coil could only 1,5 cm into the brain. Then coils that can go deeper was developed and are now being approved for some conditions like OCD. They can go 4-5 cm into the brain and affect deeper structures. Brodmann area is 7-8 cm deep into the brain. This will also reduce the need for operations to stimulate many areas. So, these new coils will likely be the treatment for depersonalization. In depersonalization many locations that are deep are active so many areas have not been open for interventions until recently. So, if they can isolate the some areas in depersonalization-likely in the prefrontal cortex- they will likely could stimulate it without operations. The same is the case in refractory depression and OCD.
Posted 29 August 2020 - 06:15 AM
experiments with highly uncertainty like psychoactive drugs or new psychopharmakas and artificial technology like neuralink is in my opion not a good idea...especially for dpdr people who have a lot of anxiety and hyperawareness and who are highly irritable over their personality, consciousness, perception or emotions,
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