The white matter disruptions found in depersonalization is more likely related to how the brain is used. . They reflects the kind networks disrupted, the overregulation of emotions. So, there are some impact on gray and white matter. You do not find atrophy or any other indication of abnormal changes in cells like in schizophrenia or neurological disorders. You are in reality trying to make the condition more serious and irreversible with thinking that should be such basis.