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Endocannabinoid Overload


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#13 Broken

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Posted 23 July 2020 - 03:58 AM

Just updated a quote that I found interesting:

"Sulak has also noticed that the use of lower doses can actually lead to increased sensitivity to cannabis over time, thus underscoring the importance of staying at low levels for the first few days of microdosing. While this is merely observational, Sulak notes that tests on animals suggest that low-level doses of THC can result in an upregulation of the endocannabinoid system (for endocannabinoid production as well as expression of its receptors).

“If you are building tolerance to THC, you are building tolerance to your body’s own cannabinoids, which are there for the purpose of promoting balance and health,” says Sulak. “So having a highly sensitive endocannabinoid system is extremely valuable for responding to illness, injury, and stress, and people can achieve that with low doses of cannabis.”

This does line up with my theory that I overloaded the system with skunk at a young age and potentially damaged receptors and brain regions with cb1 receptors.

https://www.leafly.c...sing-weed-guide

#14 Broken

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Posted 30 July 2020 - 10:31 AM

Another interesting study outlining how low doses of THC and high act in pretty opposite ways, and how science needs to change how it thinks about dosing of medications. Interesting read even if you dont agree. Also, my THC oil arrived today. Will update here, taking a few drops before bed

 

https://onlinelibrar....1111/eci.12920



#15 RunToMe

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Posted 30 July 2020 - 10:42 AM

did you start to take your micro dose ? And how is it for you ?



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Posted 30 July 2020 - 02:03 PM

I took 3 drops, which is approximately 0.15ml, which would be roughly 3mg THC in the dose that I have.  These are very rough figures, but what I intend to stick to.

 

I feel not an awful lot, but that is good and to be expected. I dont want to overly feel too much tbh. 

 

I feel my face more in a strange way, unsure if I feel more relaxed.. perhaps slightly. But could easily be placebo. This is far more easily controlled than the mushroom microdosing I did, and it shouldnt deteriorate. It is a long term project. I do perhaps feel tired, but then again I have been all day lol. So nothing to report. I am hoping the main thing that happens is improved sleep but will come back when there is more to tell



#17 Broken

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Posted 30 July 2020 - 04:24 PM

Another study outlining that "feeling high" caused by THC, is thought to be through lowered blood flow to the frontal cortex and insula. For me, when my DPD started, I described it like being high all the time. So perhaps through excessive amounts of THC these effects were made more permanent.

 

I do suspect a huge dose of CBD could help, but I did try a large amount once (300mg) but to no effect. I am hoping my microdose of THC has a positive effect on the endocannabinnoid system which I strongly suspect is involved somehow. I feel a better mood and more relaxed now, small dose. No miracles yet, but do feel I will sleep well tonight

 

https://pubmed.ncbi....h.gov/21489346/



#18 Broken

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Posted 31 July 2020 - 10:01 AM

Feel different today... cant quite pinpoint what that means yet lol. I know when I take it again tonight just before bed that I will sleep a lot better.

This is an interesting quote to through in with the theory. Perhaps CB1 receptors were internalised and therefore effectively had less receptors as a result of overloading with THC. Theory being, a microdose can up regulate receptors or an antagonist like CBD also does this

"The CB1 receptor is expressed pre-synaptically at both glutaminergic and GABAergic interneurons and, in effect, acts as a neuromodulator to inhibit release of glutamate and GABA.[16] Repeated administration of receptor agonists may result in receptor internalization and/ or a reduction in receptor protein signalling.[10]"

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Posted 01 August 2020 - 07:18 PM

I feel a definite effect on mood and relaxation. Hard to tell with sleep as last night was the hottest night of the year! Below outlines the logic with why I am doing this. So the theory is an overstimulation of the endocannabinnoid system at a young age through abuse of high THC low CBD skunk marjuana.

 

I am hoping that a very small dose will bring some life back into this system as it may have been damaged, either receptors or brain pathways, so I am hoping it will stimulate these systems. Perhaps my DP/DR I got whilst "high" was a signal of a vulnerable endocannabinoid system that was overstimulated...

 

I certainly dont feel high now on a microdose. Something I have noticed is I am able to feel my face more... strange observation. I will go on for 2 months daily until I run out

 

https://www.leafly.c...sing-weed-guide

 

"While this is merely observational, Sulak notes that tests on animals suggest that low-level doses of THC can result in an upregulation of the endocannabinoid system (for endocannabinoid production as well as expression of its receptors).

“If you are building tolerance to THC, you are building tolerance to your body’s own cannabinoids, which are there for the purpose of promoting balance and health,” says Sulak. “So having a highly sensitive endocannabinoid system is extremely valuable for responding to illness, injury, and stress, and people can achieve that with low doses of cannabis.”"



#20 Broken

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Posted 03 August 2020 - 06:40 PM

I think it's possible that the endocannabinnoid system is involved. I know it is involved with healing physical trauma and injury.. inflammation is often involved with injury.

Wouldnt be surprised if the natural endocannabinnoid system is somehow compromised either genetically or through emotional trauma. And smoking weed just shows this issue. I would zone out and dissociate on weed... after abusing the drug I am stuck in that state.

I dont believe in homeopathy, but can see how small doses of cbd/thc could help heal that system. Much like a small amount of stress is good for you like cold showers or exercise. I feel pretty good anyway and maybe am sleeping better (hard to tell with a newborn baby in the house).

It's the same with absolutely any drug. Abuse it and it does harm. Take in a sensible dose and it can heal things. THC is an incredibly powerful drug. I took 3mg yday and it felt too much. Lowered to 2mg today and felt it hit the spot more. An average spliff is about 30mg thc, and inhaling is a far quicker onset and quicker peak. Time will tell if this will work anyway.

 

Edit; So it is easy to see that a quick and fast peak just overloads that system leading to dissociation as we have a weakened "self soothing" pathway if you like. There is a woman in Scotland that has a rare gene mutation, that causes her to produce excess amounts of anandamide (our own endocannabinnoid). She feels no pain, and regularly hurts herself accidentally, and she feels no FEAR or anxiety. Imagine that? I think DPD is definitely too much anxiety/fear, either through trauma or lack of endocannabinnoids (probably both). I feel pretty good emotionally anyway, which isnt bad for 5 days low dose. Results will probably take a month or two



#21 Broken

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Posted 08 August 2020 - 07:03 PM

This is another really interesting read about how low dose THC actually acts very differently than a high dose. And low dose seems to lower glutamate activity therefore lowers anxiety. The high glutamate theory is supposedly why lamotrigine has had some success with DPD patients

Started taking this on the 30th July so has only been 10days. I feel the effect of this in terms of mood being better, but feel a little groggy as well. Heat wave makes it hard to know the cause though. I have another 6 weeks til the end of the bottle so will report back every week or two

https://profofpot.com/thc-anxiety/

#22 Broken

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Posted 12 August 2020 - 05:34 AM

Wow people really dont want to go near this topic

Another recent study showing CBD (granted 600mg in one dose) increased blood flow to the hippocampus and orbitofrontal cortex. Wishful thinking my 3mg a day might not get that result as quick but will have to see.

Old love to see a study on CBD if this actually DOES anything to the person in terms of improved memory, subjective mood/anxiety etc.

https://neuroscience...pocampus-16806/

I still feel the same tbh, but am trying to stay optimistic. Also trying to focus on just feeling more, what is happening emotionally. 99% of the time there is a feeling of fear and anxiety, almost dread, in the pit of my stomach. Seems masochistic to focus on that, but am hopeful with CBD/THC microdose it may help me process it

#23 Saibon

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Posted 12 August 2020 - 10:25 AM

Take 600 mg than

#24 Broken

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Posted 12 August 2020 - 10:51 AM

That would be about £50 in one go, I have taken a lot of gummies before.. perhaps 300mg worth. It didnt seem to do much to me or effect my DP. Maybe one day, for now I am just microdosing both THC/CBD and see what happens after a couple of months






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