The idea of using lamotrigine in depersonalization was based on a trial where a single infusion of the dissociative drug ketamine was given to healthy people and prior to the infusion 300.mg lamotrigine was given. The trial claimed that lamotrigine could block the dissociative effect of ketamine. That trial the becomes the basis for given lamotrigine in depersonalization as mono therapy and in that trial no responded to it. The combination antidepressants with lamotrigine came up and some had a response. It is not a formal treatment and everything related to depersonalization is small trials and dataset. That makes it the risk of replications errors extremely high. In normal medicin the replication is 50%. So, there is 50% chance that large errors will be in a trial and others can not replicate and do the same findings. So, one can not find answers to many things Even if the ambitions is ther. We do not know anything about most psychiatric conditions. We do not know how many drugs works. So, you can try to look for answers that can not be given. If a combination of lamotrigine and a antidepressant doesn’t work one can try and replace it with a antidepressant form other class of antidepressant. But, there is no formel medical treatment for depersonalization where a significant numbers respond with a significant reduction in symptoms and if there is no effect it might be the explanation.But, it worth a try as some have a benefit for it.