I took paxil for 10 years. I wouldn't say "numbing" was a side effect. It had unwanted sexual side effects in that it mitigated the orgasm sensation somewhat.
I took effexor for 10 years. Not significantly different than paxil.
I took Lexapro for a few years. It had the lowest side effect profile for me. I had no side effects with it and it was as effective as the others. I took 40mg/day, which
a pharmacist commented was a rather large dose. lol
I found my relief in ECT. I had it in 2014 and I dropped all meds 6 months out from that, with no symptoms of depression or anxiety since,
the first time in 40 years.