"Ketamine in Psychiatry: How It Affects Depression, Anxiety, and More (Introduction)." The Drug Classroom. - Mental & Physical Health - Depersonalization Community

Jump to content


Please Read the Community Forum Guidelines Before Posting.


Photo

"Ketamine in Psychiatry: How It Affects Depression, Anxiety, and More (Introduction)." The Drug Classroom.


  • Please log in to reply
3 replies to this topic

#1 Where

Where

    Senior DPSelfhelp.com Member

  • Moderators
  • 718 posts

Posted 10 July 2020 - 10:35 AM



#2 Mayer-Gross

Mayer-Gross

    Great Contributor

  • DPSH Members
  • 437 posts
  • LocationDenmark

Posted 10 July 2020 - 10:47 AM

Ketamine is a dissociative drug that can make depersonlisation. The idea of useing lamotrigine for depersonalisation came from a trail that showed that the dissociative effect from ketamine could be blocked by lamotrigine. That trail can likely not be replicated and it likely  because that it has later been shown that the dissociative effect from ketamine do not come from the blocking of the NMDA receptor but from the effect ketamine have on the kappa opiopid receptor. Ketamine is also a Kappa agonist. 
 

https://jamanetwork....larticle/481584

 

https://pubmed.ncbi....h.gov/20358363/



#3 Where

Where

    Senior DPSelfhelp.com Member

  • Moderators
  • 718 posts

Posted 10 July 2020 - 10:48 AM

Lamotrigine doesn't really block ketamine?

#4 Mayer-Gross

Mayer-Gross

    Great Contributor

  • DPSH Members
  • 437 posts
  • LocationDenmark

Posted 10 July 2020 - 11:13 AM

No, i don`t think so. If you take all publications within medicine there are what is called a “replication crisis”. Only 50% of trails and findings can be replicated. If you take recent brain scans done in depersonalisation they are very aware of that. Write that there could be errors, a finding needs to be replicated by others ect. A general problem is depersonalisation research is that so few do research into it, the groups in brain studies are very small and in trails too. Often less than 10.patients. So, the replications might be less than 50%. 

 

This trail have never been replicated by others and it might not be so. It might explain why lamotrigine as mono-therapy didn’t work and so few respond to it in a combination with a SSRI.

 

if you have an interest in research you have to be skeptical and aware that at least 50% might not be replicated. 






0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users