I think it was the ECT (ElectroConvulsiveTherapy) that made a huge difference for me. I had a series of 8 or 9 shocks ( induced grand mal seizures). They were painless. I had some minor memory loss which I believe has been fully restored. I have taken several SSRIs and had noticeable but manageable side effects from paxil and Effexor. I have none from Lexapro.